abstract：BACKGROUND:After E. coli O157, E. coli O26 is the second most prevalent enterohaemorrhagic E. coli (EHEC) serotype identified in cases of foodborne illness in Australia and throughout the world. E. coli O26 associated foodborne outbreaks have drawn attention to the survival capabilities of this organism in a range of e...

journal_title：BMC microbiology

authors： Lajhar SA,Brownlie J,Barlow R

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Antimicrobial resistance is currently a major global issue. As the rate of emergence of antimicrobial resistance has superseded the rate of discovery and introduction of new effective drugs, the medical arsenal now is experiencing shortage of effective drugs to combat diseases, particularly against diseases ...

journal_title：BMC microbiology

authors： Teh CH,Nazni WA,Nurulhusna AH,Norazah A,Lee HL

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:Mob family proteins are conserved between animals, plants and fungi and are essential for the activation of NDR kinases that control crucial cellular processes like cytokinesis, proliferation and morphology. RESULTS:We identified a hypomorphic allele of ChMOB2 in a random insertional mutant (vir-88) of the ...

journal_title：BMC microbiology

authors： Schmidpeter J,Dahl M,Hofmann J,Koch C

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:Gene knockouts are a common tool used to study gene function in various organisms. However, designing gene knockouts is complicated in viruses, which frequently contain sequences that code for multiple overlapping genes. Designing mutants that can be traced by the creation of new or elimination of existing r...

journal_title：BMC microbiology

authors： Taylor LJ,Strebel K

更新日期：2017-01-07 00:00:00

abstract：BACKGROUND:Access to potable water remains a major challenge particularly in resource-limited settings. Although the potential contaminants of water are varied, enteric pathogenic protozoa are known to cause waterborne diseases greatly. This study aimed at investigating the prevalence, characteristics and correlates of...

journal_title：BMC microbiology

authors： Nsoh FA,Wung BA,Atashili J,Benjamin PT,Marvlyn E,Ivo KK,Nguedia AJ

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI). Therefore, elderly care home residents are considered particularly vulnerable to the infection. The main objecti...

journal_title：BMC microbiology

authors： Rodriguez C,Taminiau B,Korsak N,Avesani V,Van Broeck J,Brach P,Delmée M,Daube G

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Despite the high prevalence of genotype 1b hepatitis C virus (HCV) among patients, a cell culture system that permits entire viral life cycle of genotype 1b isolates is limited. To develop a cell-cultured hepatitis C virus (HCVcc) of genotype 1b, the proper combination of HCV genomic variants and host cells ...

journal_title：BMC microbiology

authors： Mori KI,Matsumoto A,Maki N,Ichikawa Y,Tanaka E,Yagi S

更新日期：2016-09-27 00:00:00

abstract：BACKGROUND:There is a rapid emergence of multiple resistant gram-negative bacteria due to overuse of antibiotics in the treatment of infections. Biofilms consist of polymicrobial communities that survive the host's defense system. The key bacteria in biofilms are slow growing and support an attachment and rapid growth ...

journal_title：BMC microbiology

authors： Wu C,Nakka S,Mansouri S,Bengtsson T,Nayeri T,Nayeri F

更新日期：2016-09-09 00:00:00

abstract：BACKGROUND:Enteroaggregative (EAEC) and Shiga-toxin producing Escherichia coli (STEC) are a major cause of diarrhea worldwide. E. coli carrying both virulence factors characteristic for EAEC and STEC and producing extended-spectrum beta-lactamase caused severe and protracted disease during an outbreak of E. coli O104:H...

journal_title：BMC microbiology

authors： Trung NV,Nhung HN,Carrique-Mas JJ,Mai HH,Tuyen HT,Campbell J,Nhung NT,Van Minh P,Wagenaar JA,Mai NT,Hieu TQ,Schultsz C,Hoa NT

更新日期：2016-09-09 00:00:00

abstract：BACKGROUND:This study evaluated how dosing regimen for intramuscularly-administered ampicillin, composition of Escherichia coli strains with regard to ampicillin susceptibility, and excretion of bacteria from the intestine affected the level of resistance among Escherichia coli strains in the intestine of nursery pigs....

journal_title：BMC microbiology

authors： Ahmad A,Zachariasen C,Christiansen LE,Græsbøll K,Toft N,Matthews L,Nielsen SS,Olsen JE

更新日期：2016-09-06 00:00:00

abstract：BACKGROUND:Ophiocordyceps sinensis (DongChong XiaCao (DCXC) in Chinese), a fungal parasite of caterpillars, is a traditional Chinese medicine. Bioactive components isolated from natural DCXC possess a wide range of pharmacological actions. Many efforts have been directed towards isolating the fungi based on culture-dep...

journal_title：BMC microbiology

authors： Xia F,Liu Y,Guo MY,Shen GR,Lin J,Zhou XW

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Globally, staphylococci have developed resistance to many antibiotics. New approaches to chemotherapy are needed and one such approach could be to use plant derived actives with conventional antibiotics in a synergestic way. The purpose of this study was to isolate α-mangostin from the mangosteen (Garcinia m...

journal_title：BMC microbiology

authors： Phitaktim S,Chomnawang M,Sirichaiwetchakoon K,Dunkhunthod B,Hobbs G,Eumkeb G

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:The Bacillus anthracis S-layer protein, BslA, plays a crucial role in mammalian infection. BslA is required to mediate adherence between host cells and vegetative forms of bacteria and this interaction promotes target organs adherence and blood-brain barrier (BBB) penetration in vivo. This study attempts to ...

journal_title：BMC microbiology

authors： Wang Y,Wei Y,Yuan S,Tao H,Dong J,Zhang Z,Tian W,Liu C

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Generation of extended- spectrum β- lactamases is one of the major mechanisms by which clinical Klebsiella pneumoniae develop resistance to antibiotics. Combined antibiotics prove to be a relatively effective method of controlling such resistant strains. Some of Chinese herbal active ingredients are known to...

journal_title：BMC microbiology

authors： Cai W,Fu Y,Zhang W,Chen X,Zhao J,Song W,Li Y,Huang Y,Wu Z,Sun R,Dong C,Zhang F

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Streptococcus agalactiae (GBS) is a common pathogen to infect newborn, woman, the elderly, and immuno-compromised human and fish. 37 fish isolates and 554 human isolates of the GBS in 2007-2012 were investigated in serotypes, antibiotic susceptibility, genetic difference and pathogenicity to tilapia. RESULT...

journal_title：BMC microbiology

authors： Chu C,Huang PY,Chen HM,Wang YH,Tsai IA,Lu CC,Chen CC

更新日期：2016-08-02 00:00:00

abstract：BACKGROUND:The emergence and spread of multidrug resistant methicillin-resistant Staphylococcus aureus (MDR-MRSA) has serious health consequences in the presence of sub-MIC antibiotics. Therefore, this study was designed to evaluate β-lactamase activity, efflux activity, biofilm formation, and gene expression pattern i...

journal_title：BMC microbiology

authors： Jo A,Ahn J

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:Malic enzymes decarboxylate the tricarboxylic acid (TCA) cycle intermediate malate to the glycolytic end-product pyruvate and are well positioned to regulate metabolic flux in central carbon metabolism. Despite the wide distribution of these enzymes, their biological roles are unclear in part because the rea...

journal_title：BMC microbiology

authors： Zhang Y,Smallbone LA,diCenzo GC,Morton R,Finan TM

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Members of the genus Bifidobacterium are anaerobic Gram-positive Actinobacteria, which are natural inhabitants of human and animal gastrointestinal tract. Certain bifidobacteria are frequently used as food additives and probiotic pharmaceuticals, because of their various health-promoting properties. Due to t...

journal_title：BMC microbiology

authors： Jarocki P,Podleśny M,Komoń-Janczara E,Kucharska J,Glibowska A,Targoński Z

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:Plant cell wall degrading enzymes (PCWDEs) are a subset of carbohydrate-active enzymes (CAZy) produced by plant pathogens to degrade plant cell walls. To counteract PCWDEs, plants release PCWDEs inhibitor proteins (PIPs) to reduce their impact. Several transgenic plants expressing exogenous PIPs that interac...

journal_title：BMC microbiology

authors： Chang HX,Yendrek CR,Caetano-Anolles G,Hartman GL

更新日期：2016-07-12 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is the predominant pathogen associated with the decline of pulmonary function in cystic fibrosis (CF) patients. Both environment-to-host acquisition and patient-to-patient transmission have been described for P. aeruginosa infection. Epidemic clones and bacterial phenotypic adaptation ...

journal_title：BMC microbiology

authors： Cigana C,Melotti P,Baldan R,Pedretti E,Pintani E,Iansa P,De Fino I,Favari F,Bergamini G,Tridello G,Cirillo DM,Assael BM,Bragonzi A

更新日期：2016-07-11 00:00:00

abstract：BACKGROUND:Next-generation sequencing platforms have revolutionised our ability to investigate the microbiota composition of complex environments, frequently through 16S rRNA gene sequencing of the bacterial component of the community. Numerous factors, including DNA extraction method, primer sequences and sequencing p...

journal_title：BMC microbiology

authors： Fouhy F,Clooney AG,Stanton C,Claesson MJ,Cotter PD

更新日期：2016-06-24 00:00:00

abstract：BACKGROUND:Clostridium termitidis CT1112 is an anaerobic, Gram-positive, mesophilic, spore-forming, cellulolytic bacterium, originally isolated from the gut of a wood feeding termite Nasusitermes lujae. It has the ability to hydrolyze both cellulose and hemicellulose, and ferment the degradation products to acetate, fo...

journal_title：BMC microbiology

authors： Munir RI,Spicer V,Krokhin OV,Shamshurin D,Zhang X,Taillefer M,Blunt W,Cicek N,Sparling R,Levin DB

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Fusobacterium nucleatum, a well studied bacterium in periodontal diseases, appendicitis, gingivitis, osteomyelitis and pregnancy complications has recently gained attention due to its association with colorectal cancer (CRC) progression. Treatment with berberine was shown to reverse F. nucleatum-induced CRC ...

journal_title：BMC microbiology

authors： Kumar A,Thotakura PL,Tiwary BK,Krishna R

更新日期：2016-05-12 00:00:00

abstract：BACKGROUND:The emergence of antibiotic resistant pathogenic bacteria has reduced our ability to combat infectious diseases. At the same time the numbers of new antibiotics reaching the market have decreased. This situation has created an urgent need to discover novel antibiotic scaffolds. Recently, the application of p...

journal_title：BMC microbiology

authors： Hoerr V,Duggan GE,Zbytnuik L,Poon KK,Große C,Neugebauer U,Methling K,Löffler B,Vogel HJ

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Most lactic acid bacteria are non-motile but some of them are flagellated and exhibit motility. So far, motile lactobacilli have rarely been studied, and characteristics of their flagellins are poorly understood. In this study, a highly motile strain of Lactobacillus agilis was recruited for transcriptional ...

journal_title：BMC microbiology

authors： Kajikawa A,Midorikawa E,Masuda K,Kondo K,Irisawa T,Igimi S,Okada S

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:Lyme borrelia genotypes differ in their capacity to cause disseminated disease. Gene array analysis was employed to profile the host transcriptome induced by Borrelia burgdorferi strains with different capacities for causing disseminated disease in the blood of C3H/HeJ mice during early infection. RESULTS:B...

journal_title：BMC microbiology

authors： Petzke MM,Iyer R,Love AC,Spieler Z,Brooks A,Schwartz I

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:Diazotrophic (nitrogen-fixing) Gram-positive and endospore-formed Paenibacillus spp. have potential uses as a bacterial fertilizer in agriculture. The transcriptional analysis of nitrogen fixation in Paenibacillus is lacking, although regulation mechanisms of nitrogen fixation have been well studied in Gram-...

journal_title：BMC microbiology

authors： Shi HW,Wang LY,Li XX,Liu XM,Hao TY,He XJ,Chen SF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:It is unclear how DNA is packaged in a bacterial cell in the absence of nucleosomes. To investigate the initial level of DNA condensation in bacterial nucleoid we used in vivo DNA digestion coupled with high-throughput sequencing of the digestion-resistant fragments. To this end, we transformed E. coli cells...

journal_title：BMC microbiology

authors： Tolstorukov MY,Virnik K,Zhurkin VB,Adhya S

更新日期：2016-02-20 00:00:00

abstract：BACKGROUND:The genus Lactobacillus belongs to a large heterogeneous group of low G + C Gram-positive anaerobic bacteria, which are frequently used as probiotics. The health-beneficial effects, in particular the immunomodulation effect, of probiotics depend on the strain and dose used. Strain variations may be related t...

journal_title：BMC microbiology

authors： Górska S,Buda B,Brzozowska E,Schwarzer M,Srutkova D,Kozakova H,Gamian A

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:In this study, we have evaluated the immunological status of hepatitis C virus (HCV)-infected patients aiming at identifying putative biomarkers associated with distinct degrees of liver fibrosis. Peripheral blood and tissue T-cells as well as cytokine levels were quantified by flow cytometry. RESULTS:Data ...

journal_title：BMC microbiology

authors： de Souza-Cruz S,Victória MB,Tarragô AM,da Costa AG,Pimentel JP,Pires EF,Araújo Lde P,Coelho-dos-Reis JG,Gomes Mde S,Amaral LR,Teixeira-Carvalho A,Martins-Filho OA,Victória Fda S,Malheiro A

更新日期：2016-01-07 00:00:00

abstract：BACKGROUND:Saccharomyces cerevisiae multicellular communities are sustained by a scaffolding extracellular matrix, which provides spatial organization, and nutrient and water availability, and ensures group survival. According to this tissue-like biology, the yeast extracellular matrix (yECM) is analogous to the higher...

journal_title：BMC microbiology

authors： Faria-Oliveira F,Carvalho J,Ferreira C,Hernáez ML,Gil C,Lucas C

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:Nucleotide sugar transporters (NSTs) play an essential role in translocating nucleotide sugars into the lumen of the endoplasmic reticulum and Golgi apparatus to be used as substrates in glycosylation reactions. This intracellular transport is an essential step in the biosynthesis of glycoconjugates. RESULT...

journal_title：BMC microbiology

authors： Baptista CG,Rodrigues EC,Morking P,Klinke A,Zardo ML,Soares MJ,de Aguiar AM,Goldenberg S,Ramos AS

更新日期：2015-11-21 00:00:00

abstract：BACKGROUND:Bloodstream infections represent serious conditions carrying a high mortality and morbidity rate. Rapid identification of microorganisms and prompt institution of adequate antimicrobial therapy is of utmost importance for a successful outcome. Aiming at the development of a rapid, simplified and efficient pr...

journal_title：BMC microbiology

authors： Jakovljev A,Bergh K

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Chlamydia pneumoniae is a common human pathogen that is associated with upper and lower respiratory tract infections. It has also been suggested that C. pneumoniae infection can trigger or promote a number of chronic inflammatory conditions, including asthma and atherosclerosis. Several strains of C. pneumon...

journal_title：BMC microbiology

authors： He X,Liang Y,LaValley MP,Lai J,Ingalls RR

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Enteropathogenic Escherichia coli (EPEC) are classified into typical and atypical strains based on the presence of the E. coli adherence factor (EAF) plasmid. The EAF plasmid contains the bfp (bundle-forming pilus) operon and the perABC (plasmid encoded regulator) gene cluster. A 1-kb cryptic region of EAF p...

journal_title：BMC microbiology

authors： Teixeira NB,Rojas TC,da Silveira WD,Matheus-Guimarães C,Silva NP,Scaletsky IC

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:Prevotella intermedia is a Gram-negative black-pigmenting oral anaerobe associated with periodontitis in humans, and has a haem requirement for growth, survival and virulence. It produces an iron porphyrin-containing pigment comprising monomeric iron (III) protoporphyrin IX (Fe(III)PPIX.OH; haematin). The ba...

journal_title：BMC microbiology

authors： Byrne DP,Manandhar SP,Potempa J,Smalley JW

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Classical bacteriological characteristics of Salmonella enterica indicate that the members of this species are unable to utilize lactose as a carbon source. However, lactose-fermenting (Lac+) strains of several Salmonella serovars have been isolated from different foodborne outbreaks as well as different geo...

journal_title：BMC microbiology

authors： Leonard SR,Lacher DW,Lampel KA

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:The phytohormone indole-3-acetic acid (IAA) is widely distributed among plant-associated bacteria. Certain strains of the Pseudomonas syringae complex can further metabolize IAA into a less biologically active amino acid conjugate, 3-indole-acetyl-ε-L-lysine, through the action of the iaaL gene. In P. syring...

journal_title：BMC microbiology

authors： Castillo-Lizardo MG,Aragón IM,Carvajal V,Matas IM,Pérez-Bueno ML,Gallegos MT,Barón M,Ramos C

更新日期：2015-08-19 00:00:00

abstract：BACKGROUND:Non-ribosomal peptide synthetase (NRPS) enzymes govern the assembly of amino acids and related monomers into peptide-like natural products. A key goal of the field is to develop methods to effective recombine NRPS domains or modules, and thereby generate modified or entirely novel products. We previously sho...

journal_title：BMC microbiology

authors： Calcott MJ,Ackerley DF

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:Ureaplasma urealyticum is a major pathogen associated with many diseases. The ability of U. urealyticum to protect itself from oxidative stress is likely to be important for its pathogenesis and survival, but its oxidative stress tolerance mechanisms remain unclear. This study investigates the antioxidant ac...

journal_title：BMC microbiology

authors： Dai G,Li R,Chen H,Jiang C,You X,Wu Y

更新日期：2015-07-26 00:00:00